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Evaluation of vitamin D supplement effect in patients with depression

Evaluation of vitamin D supplement effect in patients with depression

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250624066244N1
Enrollment
104
Registered
2025-08-12
Start date
2025-08-21
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depression. Major depressive disorder, single episode, severe without psychotic features

Interventions

Intervention 1: Intervention group: After receiving the necessary explanations to participate in the study and completing the PHQ-9 questionnaire, patients in the intervention group will receive 2 pea

Sponsors

Yazd Azad University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: The patient has been diagnosed with Major Depressive Disorder and is currently undergoing treatment The patient is in the maintenance phase of treatment

Exclusion criteria

Exclusion criteria: The patient must not have a history of vitamin D supplementation within the past month. The patient must not be currently taking digoxin. The patient must not have a history of nephrolithiasis The patient must not have a history of renal failure The patient must not have a history of hypercalcemia The patient must not have a known hypersensitivity to vitamin D supplements The patient must not have a history of histoplasmosis The patient must not have a history of parathyroid disorders The patient must not have a history of lymphoma The patient must not have a history of sarcoidosis

Design outcomes

Primary

MeasureTime frame
Depression score on the PHQ-9 questionnaire and the score on each of the 9 items of the questionnaire. Timepoint: At the beginning of the study and one month after receiving the supplement or placebo. Method of measurement: PHQ-9 questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Behjatiabadeh

The Islamic Azad University Yazd Ali ibn Abitaleb Medical School

javad.behjatiabadeh@iau.ir+98 71 4435 4445

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026