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Evaluation of the Effect of Insulin Drops in the Treatment of Corneal Neurotrophic Ulcers

Evaluation of the Effect of Insulin Drops in the Treatment of Corneal Neurotrophic Ulcers: A Randomized Clinical Trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250623066235N1
Enrollment
36
Registered
2025-09-07
Start date
2025-09-06
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurotrophic Ulcers. Corneal pigmentations and deposits

Interventions

Intervention 1: Intervention group: Intervention Group: One cc of Regular Insulin (100 Units Per cc, Eksir Daru Co.) Was Combined with Four cc of Preservative-Free Artificial Tears (Sinalon, Sina Daru

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who Have Only Clinical Findings of Chronic Pees and Discomfort and Foreign Body Sensation after Confirmation by a Corneal Specialist. Patients who have PED after Confirmation by a Corneal Specialist.

Exclusion criteria

Exclusion criteria: Pregnant or Breastfeeding Women Patients Who, for any Reason, Refuse to Continue Treatment or are Unable to go for f/u. Patients who have Corneal Perforation or are Candidates for Corneal Transplant Surgery due to Progression to Perforation.

Design outcomes

Primary

MeasureTime frame
Wound Healing in Patients with Neurotrophic Ulcers. Timepoint: All Patients will be Examined by the Researcher Four Times, one Week Apart, and the Process of Changes will be Recorded. Method of measurement: The Extent of Eye Involvement in Terms of the Size of the Epithelial Defect, The Presence of Infiltration, and the Patients' Vision will be Examined, and the Two Groups will be Recorded and Compared by the Researcher. Then, The Results of The Examination will be Reported to The Cornea Fellowship and a Decision will be Made Regarding Continued Treatment.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMilad Azh

Kerman University of Medical Sciences

milad.azh92@gmail.com+98 34 3211 5781

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026