Investigation of Selective Serotonin Reuptake Inhibitors on Complex Regional Pain Syndrome in Hospitalized Patients

Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) on the Incidence of Complex Regional Pain Syndrome (CRPS) Following Distal Radius Fracture in Patients with Major Depressive Disorder, Obsessive-Compulsive Disorder, and Anxiety Disorders: A Randomized Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250623066231N1

Enrollment

Registered

2025-11-26

Start date

2025-10-07

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fracture at wrist and hand level. Fracture at wrist and hand level

Interventions

Intervention 1: Intervention group: Patients will receive 25 mg sertraline tablet (Sobhan Pharmaceutical Co.) once daily for 14 days. Then the dose will be increased to 50 mg daily and continued for 6

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with a confirmed diagnosis of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), or anxiety disorder by a qualified psychiatrist. Patients with a recent distal radius fracture confirmed by radiological imaging. Age between 18 to 65 years old. Provision of written informed consent to participate in the study. No prior history of complex regional pain syndrome (CRPS) or other chronic pain syndromes before the fracture.

Exclusion criteria

Exclusion criteria: History or presence of Complex Regional Pain Syndrome (CRPS) prior to study enrollment. Presence of severe chronic medical conditions such as advanced autoimmune diseases or active malignancies. History of hypersensitivity or intolerance to selective serotonin reuptake inhibitors (SSRI).

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Before intervention, and 2, 6, 8 weeks after intervention. Method of measurement: Visual Analogue Scale.;Range of Motion. Timepoint: Before intervention, and 2, 6, 8 weeks after intervention. Method of measurement: Goniometry.;Edema. Timepoint: Before intervention, and 2, 6, 8 weeks after intervention. Method of measurement: Circumferential Measurement.;Abnormal sudomotor Signs. Timepoint: Before intervention, and 2, 6, 8 weeks after intervention. Method of measurement: Thermography.	—

Measure

Time frame

Pain. Timepoint: Before intervention, and 2, 6, 8 weeks after intervention. Method of measurement: Visual Analogue Scale.;Range of Motion. Timepoint: Before intervention, and 2, 6, 8 weeks after intervention. Method of measurement: Goniometry.;Edema. Timepoint: Before intervention, and 2, 6, 8 weeks after intervention. Method of measurement: Circumferential Measurement.;Abnormal sudomotor Signs. Timepoint: Before intervention, and 2, 6, 8 weeks after intervention. Method of measurement: Thermography.

—

Secondary

Measure	Time frame
Wrist Dysfunction. Timepoint: Before intervention and 8 week after intervention. Method of measurement: Goniometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Sadegh Sabahi

Mashhad University of Medical Sciences

sadeghsabahi77@gmail.com+98 51 3801 2638

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026