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A comparative study of the efficacy of piroxicam ampoule mesotherapy injection and shockwave modality on the clinical manifestations of knee osteoarthritis patients

A comparative study of the efficacy of piroxicam ampoule mesotherapy injection and shockwave modality on the clinical manifestations of knee osteoarthritis patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250622066221N1
Enrollment
60
Registered
2025-08-18
Start date
2025-09-02
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of knee. Osteoarthritis of knee

Interventions

The first intervention group: Patients received subcutaneous injections containing a combination of 20 mg, 1 ml of piroxicam and 5 cc of lidocaine 2%, in acupuncture points ST34, ST35, SP9, BL 38, SP1

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 75 Years

Inclusion criteria

Inclusion criteria: Mild to moderate knee osteoarthritis

Exclusion criteria

Exclusion criteria: Injections in or around the knee joint in the last three months . Use of NSIAD in the last three days .History of cancer ,diabetes ,rheumatological disease and vascular collagen .Heat and redness in the knee ,History of knee injury ,History of knee Arthroplasty or other surgeries on the knee ,Presence of active Radiculopathy ,myopathy ,peripheral neuropathy ,Pregnancy or breastfeeding ,BMI>42 ,Allergy to piroxicam and other NSAID ,Severe gastrointestinal ,cardiovascular ,liver and kidney disease ,Any serious systemic or local infection such as brucellosis , Patients who have other musculoskeletal complications which Causes lower limb pain like secondary arthritis ,Patients who do Not complete the informed consent form to participate in the Study .

Design outcomes

Primary

MeasureTime frame
Osteoarthritis of knee. Timepoint: Measurement of knee joint cartilage thickness and evaluation of knee effusion before immediately after and one month after injection of piroxicam ampoule and shockwave modality. Method of measurement: Visual analog scale , western Ontario and Mc master universities arthritis index , Oxford knee scale.

Secondary

MeasureTime frame
Improve pain and function. Timepoint: Investigation of pain improvement and performance ten days and one month after piroxicam mesotherapy injection and shockwave modality. Method of measurement: Visual analog scale , Western Ontario and Mc Master universities arthritis index ,oxford knee scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRamin Ardeshiri

Shiraz University of Medical Sciences

ramin.ardeshiri@gmail.com+98 83 3835 3624

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026