“Evaluation of Dexamethasone's Effect on the Weaning Process from Mechanical Ventilation in Poisoned Patients”

Investigating the use of dexamethasone in the weaning process of poisoned patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250621066212N1

Enrollment

Registered

2025-06-29

Start date

2025-07-11

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

"Acute poisoning (with any toxic substance) leading to respiratory failure and the need for intubation and mechanical ventilation". T36-T50

Interventions

Intervention group: "Intravenous dexamethasone administration"/ Dosage: 8 mg three times for three days by intravenous route.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Age >18 years No contraindications to corticosteroid administration (e.g., patients with diabetes mellitus will be excluded)

Exclusion criteria

Exclusion criteria: Inclusion Criteria: Age >18 years No contraindications to corticosteroid administration (e.g., patients with diabetes mellitus will be excluded)

Design outcomes

Primary

Measure	Time frame
"Success in the weaning process (successful cessation of mechanical ventilation)"Operational definition: "The ability to maintain spontaneous breathing without the need for a ventilator for at least 48 hours after extubation"Method of measurement:"Recording the patient's respiratory status and the absence of the need for reintubation within 48 hours after extubation"Unit of measurement:"Percentage of patients with successful weaning". Timepoint: For the outcome variable "Success in weaning":"Measurement at two time points:Before starting the weaning protocol (initial assessment of the patient's condition)48 hours after extubation (confirmation of successful weaning)"**2. For the outcome variable "Duration of intubation":"Continuous measurement:Accurate recording of the time of intubation start and time of successful extubation in the patient's file"3. For the outcome variable "RSBI index":"Measurement at time points:Before starting weaning (baseline)Every 6 hours to 24 hours after starting weaning"4. For the outcome variable "Ventilator-associated pneumonia":"Daily measurement:Assessment of symptoms (fever, leukocytosis, radiological findings) up to 48 hours after extubation". Method of measurement: 1. For the outcome variable "Success in weaning":"Measurement tool:Clinical weaning checklist based on the standard protocol of Loghman Hakim HospitalRecording of respiratory status by ICU nurses (no need for a ventilator for 48 hours after extubation)"2. For the outcome variable "Duration of intubation":"Measurement tool:Recording of exact intubation and extubation times in the hospital electronic medical record system (in hours)"3. For the outcome variable "Rapid/Assisted Respiratory Index (RSBI)":"Measurement tool:Mechanical ventilator (calculation of the ratio of respiratory frequency to tidal volume based on the ventilator display)Confirmation by an intensive care specialist"4. For the outcome variable "Ventilator-associated pneumonia":"Measurement tool:CDC diagnost	—

Measure

Time frame

"Success in the weaning process (successful cessation of mechanical ventilation)"Operational definition: "The ability to maintain spontaneous breathing without the need for a ventilator for at least 48 hours after extubation"Method of measurement:"Recording the patient's respiratory status and the absence of the need for reintubation within 48 hours after extubation"Unit of measurement:"Percentage of patients with successful weaning". Timepoint: For the outcome variable "Success in weaning":"Measurement at two time points:Before starting the weaning protocol (initial assessment of the patient's condition)48 hours after extubation (confirmation of successful weaning)"**2. For the outcome variable "Duration of intubation":"Continuous measurement:Accurate recording of the time of intubation start and time of successful extubation in the patient's file"3. For the outcome variable "RSBI index":"Measurement at time points:Before starting weaning (baseline)Every 6 hours to 24 hours after starting weaning"4. For the outcome variable "Ventilator-associated pneumonia":"Daily measurement:Assessment of symptoms (fever, leukocytosis, radiological findings) up to 48 hours after extubation". Method of measurement: 1. For the outcome variable "Success in weaning":"Measurement tool:Clinical weaning checklist based on the standard protocol of Loghman Hakim HospitalRecording of respiratory status by ICU nurses (no need for a ventilator for 48 hours after extubation)"2. For the outcome variable "Duration of intubation":"Measurement tool:Recording of exact intubation and extubation times in the hospital electronic medical record system (in hours)"3. For the outcome variable "Rapid/Assisted Respiratory Index (RSBI)":"Measurement tool:Mechanical ventilator (calculation of the ratio of respiratory frequency to tidal volume based on the ventilator display)Confirmation by an intensive care specialist"4. For the outcome variable "Ventilator-associated pneumonia":"Measurement tool:CDC diagnost

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPeyman Erfan Talab Evini

Shahid Beheshti University of Medical Sciences

peyman1346erfan@gmail.com+98 21 5541 9005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026