Melatonin in Pain management

Comparison of the Effect of High and Low Doses of Melatonin vs. Placebo on the Need for Sedatives and Opioids for Pain Management in Ventilator-Dependent Multiple Trauma Patients in the Intensive Care Unit: A Double-Blind Randomized Clinical Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250608066119N1

Enrollment

Registered

2025-07-18

Start date

2025-07-07

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-Dependent Multiple Trauma Patient in the Intensive Care Unit. -

Interventions

Intervention 1: Control group: Two placebo tablets manufactured at the Ahvaz University of Medical Sciences. Intervention 2: Intervention group: One 3 mg sublingual melatonin tablet (Vanatonin, manufa

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: The informed consent form should be completed by them or their legal guardian. They are over 18 years of age. They are hospitalized in the intensive care unit. They require mechanical ventilation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Prescribed opioid analgesic dose. Timepoint: every 24 hours. Method of measurement: Ratio scale (milligrams).;Prescribed non-opioid analgesic dose. Timepoint: every 24 hours. Method of measurement: Ratio scale (milligrams).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMandana Izadpanah

Ahvaz University of Medical Sciences

izadpanah-m@ajums.ac.ir+98 61 3373 8378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026