Hemodynamic responses to laryngoscopy and endotracheal intubation under general anesthesia. Bradycardia, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group will receive lidocaine at a dose of 1.5 mg per kilogram of body weight administered as a slow intravenous injection one to two minutes prior
Sponsors
Alborz University Of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 65 years Candidates for elective surgery requiring intubation and laryngoscopy ASA physical status class I and II Written informed consent for participation No contraindication to lidocaine or oxytocin No known allergy to standard anesthetic agents Systolic blood pressure >90 mmHg and heart rate >60 bpm
Exclusion criteria
Exclusion criteria: Pregnancy History of cardiovascular diseases (e.g. arrhythmia or tachycardia) Chronic respiratory diseases Neurological disorders Hepatic or renal disease History of substance abuse or stimulant use Anticipated difficult intubation (e.g. short neck, large tongue, small jaw) Known allergy to lidocaine or oxytocin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in patients' systolic blood pressure following endotracheal intubation. Timepoint: Systolic blood pressure will be measured before administration of intervention, immediately before endotracheal intubation, and at one, three, and five minutes after intubation. Method of measurement: Systolic blood pressure will be measured using a non-invasive hospital-grade blood pressure monitor.;Change in patients' diastolic blood pressure following endotracheal intubation. Timepoint: Before intervention, immediately before intubation, and at one, three, and five minutes after intubation. Method of measurement: Measured using a non-invasive hospital-grade blood pressure monitor.;Change in patients' heart rate following endotracheal intubation. Timepoint: Before intervention, immediately before intubation, and at one, three, and five minutes after intubation. Method of measurement: Measured using hospital electrocardiographic heart rate monitor. | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of cardiac arrhythmias following endotracheal intubation in patients receiving lidocaine or oxytocin. Timepoint: From the beginning of intervention up to five minutes after intubation. Method of measurement: Continuous monitoring using hospital electrocardiographic system.;Change in mean arterial blood pressure (MAP) following endotracheal intubation. Timepoint: Before intervention, immediately before intubation, and at one, three, and five minutes after intubation. Method of measurement: Calculated from systolic and diastolic values measured using a non-invasive monitor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdi Rezai
Alborz University Of Medical Sciences
Outcome results
None listed