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Effect of tranexamic acid injection on postoperative edema, bleeding, and ecchymosis in rhinoplasty.

Effect of tranexamic acid injection before external osteotomy on postoperative edema, bleeding, and ecchymosis in rhinoplasty in patients requiring nasal surgery requiring rhinoplasty surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250605066067N1
Enrollment
120
Registered
2025-07-07
Start date
2025-06-22
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinoplasty. Encounter for cosmetic surgery

Interventions

Intervention 1: Control group: In this group, to control bleeding and edema and ecchymosis, a dose of 10 mg of normal saline as a placebo (Caspian Tamin Company) is injected intravenously before the s

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Patient who need primary rhinoplasty Medium skin thickness of the nose Patient who need low to high osteotomy Patient Informed consent

Exclusion criteria

Exclusion criteria: History of previous or current medical conditions including stomach ulcers, diabetes mellitus, high blood pressure, blood and clotting disorders Patients with allergic reactions to tranexamic acid Have used anticoagulant treatments 5 days before surgery

Design outcomes

Primary

MeasureTime frame
Amount of bleeding during surgery. Timepoint: At the time of surgery. Method of measurement: To determine the amount of bleeding, the cumulative volume of bleeding will be calculated by adding the total volume of blood aspirated and the number of surgical gauzes completely filled with blood. To calculate the volume of blood collected by the gauzes, the volume of blood that can be collected by each standard gauze (20 x 20 cm) was previously measured to be 7 ml and then multiplied by the number of gauzes used in the surgery.;Edema. Timepoint: On days 1, 3, and 7 after surgery. Method of measurement: Edema were assessed based on the scale described by Gurlek et al. and the degree of edema was scored between 0 and 4.;Ecchymosis. Timepoint: On days 1, 3, and 7 after surgery. Method of measurement: ecchymosis were assessed based on the scale described by Gurlek et al. and the degree of ecchymosis was scored between 0 and 4.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNiloufar Arianpour

Ahvaz University of Medical Sciences

drniloufararianpour@gmail.com+98 61 3320 5168

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026