Second trimester pregnancy termination
Conditions
Interventions
Intervention 1: Intervention group: Participants will receive 400 micrograms of misoprostol sublingually every 3 hours combined with insertion of a size 24 Foley catheter inflated with 30 ml of normal
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Pregnant women between 13 and 24 weeks of gestation Age between 18 and 50 years Willingness and ability to provide informed consent
Exclusion criteria
Exclusion criteria: Known allergy or hypersensitivity to misoprostol Presence of placenta accreta or percreta Suspected or confirmed septic abortion Clinical diagnosis of chorioamnionitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to complete abortion. Timepoint: Continuously measured during the intervention; final assessment within 24 hours post-intervention. Method of measurement: Recorded by medical staff from the start of the intervention until complete expulsion of fetal and placental tissue.;Abortion success rate. Timepoint: Final assessment within 24 hours post-intervention. Method of measurement: Confirmed by ultrasound examination.;Duration of uterine bleeding. Timepoint: Monitored up to 48 hours post-intervention. Method of measurement: Assessed via patient self-reporting and clinical observation.;Incidence of adverse effects. Timepoint: Evaluated up to 48 hours post-intervention. Method of measurement: Evaluated through clinical examination and patient interviews. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of uterine bleeding. Timepoint: Baseline (before intervention), immediately after abortion, and up to two weeks post-intervention. Method of measurement: Recorded using patient bleeding diary and clinical observation.;Amount of bleeding. Timepoint: Baseline, immediately after abortion, and up to two weeks post-intervention. Method of measurement: Estimated by medical staff.;Patient satisfaction. Timepoint: Baseline, immediately after abortion, and up to two weeks post-intervention. Method of measurement: Assessed using a standardized questionnaire.;Incidence of adverse effects. Timepoint: Baseline, immediately after abortion, and up to two weeks post-intervention. Method of measurement: Documented through clinical examination and patient interviews. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Maryam Mazloomi
Iran University of Medical Sciences
Outcome results
None listed