Knee Osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: All participants, following bariatric surgery, will be placed on a standardized post-surgical dietary plan consisting of a low-calorie intake (800–1000 kcal/day) su
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Individuals with a BMI over 40 who are candidates for bariatric surgery and willing to undergo the procedure. Diagnosis of knee osteoarthritis based on the American College of Rheumatology criteria and radiographic evidence according to Kellgren-Lawrence grades 2 to 4. A skeletal muscle mass to height squared ratio of less than 5.7 kg/m², or skeletal muscle mass less than 15 kg. No intra-articular injection, exercise therapy, or physiotherapy within one month prior to enrollment. Walking speed less than 1 meter per second over a 6-meter distance. Grip strength less than 27 kg in men and less than 16 kg in women. Taking more than 15 seconds to perform five chair stands (sit-to-stand test). Timed Up and Go Test result equal to or greater than 20 seconds. 400-meter walk test time equal to or more than 6 minutes.
Exclusion criteria
Exclusion criteria: History of knee or hip arthroplasty Allergy to protein-based compounds Uncontrolled hypertension Any uncontrolled cardiac or pulmonary disease Neurological or cognitive disorders Failure to complete at least 70% of the post-surgery exercise therapy program Participation in a physiotherapy program during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| KOOS Questionnaire Score. Timepoint: Before bariatric surgery, and at 1 month, 3 months. Method of measurement: Completion of KOOS form.;Knee pain. Timepoint: Before bariatric surgery, and at 1 month, 3 months. Method of measurement: Recording pain intensity on a graded paper (Visual Analogue Scale or VAS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Gait Speed. Timepoint: Before bariatric surgery, and at 1 month, 3 months. Method of measurement: Measurement of distance covered per unit of time.;Score of Timed up and go test. Timepoint: Before bariatric surgery, and at 1 month, 3 months. Method of measurement: The Timed Up and Go (TUG) test measures functional mobility by timing how long it takes a person to rise from a chair, walk 3 meters, turn around, return, and sit down. The test begins when the person starts to stand and ends once they are seated again.;Grip Strength Measurement. Timepoint: Before bariatric surgery, and at 1 month, 3 months. Method of measurement: With Isometric Dynamometer.;Chair Standing Test Score. Timepoint: Before bariatric surgery, and at 1 month, 3 months. Method of measurement: Measurement of the time it takes to stand up and sit down on a chair five times. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarideh Karimipour Haddadan
Tehran University of Medical Sciences
Outcome results
None listed