Studying the preempetive effect of ketorolac, pregabalin, and a combination of the two drugs in lumbar disc surgery

Investigating the preemptive effect of pregabalin, oral ketorolac and the combination of ketorolac and.pregabalin on pain after lumbar disc surgery under general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250601066005N1

Enrollment

120

Registered

2025-11-09

Start date

2025-10-23

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain after lumbar disc surgery. Other acute postprocedural pain

Interventions

Intervention 1: Intervention group: pregabalin 150 mg orally half an hour before the start of anesthesia. Intervention 2: Intervention group: Ketorolac 10 mg orally half an hour before the start of an

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients 18 to 80 years old Patients who are candidates for lumbar disc surgery ASA I II

Exclusion criteria

Exclusion criteria: People who are allergic to pregabalin, ketorolac, propofol, or other drugs Pregnant patients Have a clinical history or ECG evidence of heart block Ischemic heart disease patients Asthma Sleep apnea syndrome BMI>35

Design outcomes

Primary

Measure	Time frame
Determining and comparing the average pain intensity with visual analogue scale in discopathy surgery. Timepoint: From the start of surgery to discharge from recovery. Method of measurement: visual analog scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mehrdad Masoudifar

Esfahan University of Medical Sciences

reza.salehi.ylm@gmail.com+98 917 747 7585

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026