Treatment resistant depression. Major depressive disorder, recurrent
Conditions
Interventions
Intervention 1: Intervention group: Probiotic substance Geri Lact, a substance consisting of 7 bacterial strains in capsule form and produced by Zist Takhmir Company, which patients consume one capsul
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Over 60 years old Obtaining a score above 14 on the Beck Depression Inventory 2 Education at the end of primary school
Exclusion criteria
Exclusion criteria: Having a mental disorder other than depression Dementia Having a plan to commit suicide Received psychotherapy in the past 12 months Drug and food sensitivity Having physical illnesses such as immune system deficiencies Taking immunosuppressive drugs and chemotherapy Active intestinal diseases Symptoms of infection Reluctance to cooperate Taking dietary supplements containing probiotics, such as probiotic dairy products and taking omega-3 and multivitamin-mineral supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score on the Beck 2 Depression Inventory. Timepoint: Before the start of the intervention and 56 days after the start of the intervention. Method of measurement: Beck 2 depression questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression total score. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Score from the Beck questionnaire.;Social functioning score. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Average score of items related to social functioning of the Beck2 questionnaire.;Average recognition score. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Average score of items related to cognition in the Beck 2 questionnaire.;Average emotion score. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Average score of items related to emotion in the Beck Questionnaire 2.;Average physical score. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Average score of physical items of the Beck Questionnaire 2.;Average score of overt behaviors. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Average score of items related to overt behaviors of the Beck Questionnaire 2.;Severity of depression. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Average depression severity score based on Beck Depression Inventory 2. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahboubeh Alsadat Tavalaei Zavareh
Kashan University of Medical Sciences
Outcome results
None listed