peritoneal dialysis in treatment-resistant heart failure patients

Use of peritoneal dialysis in treatment-resistant patients with moderate to severe heart failure: A randomized clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250528065943N1

Enrollment

Registered

2025-07-17

Start date

2025-05-31

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate to severe treatment-resistant heart failure. Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease

Interventions

Intervention group: Among patients with moderate to severe heart failure and chronic kidney disease with a glomerular filtration rate (GFR) between 20 and 60 who currently do not require hemodialysis,

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Ejection fraction less than 20 presence of edema in lower extremities loop diuretic resistance final confirmation of the diagnosis by nephrologist and cardiologist

Exclusion criteria

Exclusion criteria: Complete Anuria (cessation of urine) patients with acute renal failure Unwillingness to participate in the study patients requiring emergency hemodialysis patients with end-stage renal disease (ESRD)

Design outcomes

Primary

Measure	Time frame
The effect of peritoneal dialysis on the improvement of respiratory indices in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Clinical symptoms related to pulmonary congestion and symptomatic dyspnea based on patients’ lung examination.;The effect of peritoneal dialysis on the improvement of lower limb edema in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Clinical examination.;The effect of peritoneal dialysis on the improvement of cardiac indices in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Cardiac Echograph (EF, Pulmonary arterial pressure).;The effect of peritoneal dialysis on the improvement of renal indices in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Kidney tests (GFR, Cr, and urine volume increase).;The effect of peritoneal dialysis on the improvement of liver indices in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Liver function tests (ALT, AST, LDH, PT).	—

Measure

Time frame

The effect of peritoneal dialysis on the improvement of respiratory indices in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Clinical symptoms related to pulmonary congestion and symptomatic dyspnea based on patients’ lung examination.;The effect of peritoneal dialysis on the improvement of lower limb edema in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Clinical examination.;The effect of peritoneal dialysis on the improvement of cardiac indices in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Cardiac Echograph (EF, Pulmonary arterial pressure).;The effect of peritoneal dialysis on the improvement of renal indices in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Kidney tests (GFR, Cr, and urine volume increase).;The effect of peritoneal dialysis on the improvement of liver indices in patients with moderate to severe heart failure and comparison with the control group. Timepoint: At the beginning of the study and 6 months later. Method of measurement: Liver function tests (ALT, AST, LDH, PT).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarahnoosh Farnood

Tabriz University of Medical Sciences

farnoodkidney@gmail.com+98 41 3177 1041

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026