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Effect of Rhubarb capsule in treatment of hypermenorrhea

Comparing the effect of Rhubarb capsule with Mefenamic acid capsule on patients with hypermenorrhea: A randomized clinical trial study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250527065942N1
Enrollment
72
Registered
2025-12-30
Start date
2025-12-29
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypermenorrhea (Heavy Menstrual Bleeding). Hypermenorrhea

Interventions

Intervention group: Participants in this group received one capsule containing 500 mg of Rheum ribes root powder, standardized for total phenolic and total flavonoid content, every 12 hours. The inter

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: The age range of 20 to 40 years with regular menstrual cycles and moderate-to-heavy menstrual bleeding with no history of known chronic illnesses with no history of pelvic inflammatory disease, fibroids, or tumors with no history of abdominal or pelvic surgery with no regular medication use with no major stressful life events in the past 6 months with no chronic constipation or hemorrhoids with no known psychiatric disorders

Exclusion criteria

Exclusion criteria: Pregnancy Uterine infection Menstrual irregularity Contraindication or hypersensitivity to anti-inflammatory drugs Pelvic pathology Acute systemic illness Anatomical problems

Design outcomes

Primary

MeasureTime frame
Change in the duration of menstrual bleeding (in hours) per menstrual cycle. Timepoint: Measured at baseline (the menstrual cycle before starting the intervention) and during each of the two consecutive treatment cycles. Method of measurement: Duration is recorded by the participant in a daily menstrual diary and verified by the researcher using a structured questionnaire. The total bleeding hours for each cycle are calculated.;Change in the volume of menstrual blood loss (in milliliters) per menstrual cycle. Timepoint: Measured at baseline (the menstrual cycle before starting the intervention) and during each of the two consecutive treatment cycles. Method of measurement: Quantified using the pictorial Higham chart. Participants record the degree of soiling for each used sanitary pad/tampon, which is then converted to an estimated blood loss volume in milliliters.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaezeh Ahanj

Tabriz University of Medical Sciences

faezeh.ahj@gmail.com+98 41 3337 9527

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026