Recurrent Pregnancy Loss .. Tacrolimus Efficacy in Patients with Recurrent Pregnancy Loss .
Conditions
Interventions
Intervention 1: Intervention group .Tacrolimus prescription. Intervention 2: Control group: Follow pregnant women without take Tacrolimus.
Sponsors
No. 971941913114? Yakhchal Street? Dr. Shariati Street, Tehran, Iran.
Eligibility
Sex/Gender
Female
Age
20 Years to 39 Years
Inclusion criteria
Inclusion criteria: Women aged between 20 and 39 years. Patients who presented for treatment of recurrent miscarriage (three or more miscarriages before 12 weeks of gestation, with documented fetal heart rate [FHR]). Patients with unexplained infertility despite evaluation, including assessment of ovulatory function, tubal patency, uterine anatomical abnormalities, cervical factors, and sperm quality and quantity. Patients who are able to continue regular follow-up visits during the study period.
Exclusion criteria
Exclusion criteria: Patients using immunosuppressive medications for infertility treatment, such as azathioprine, mizoribine, mycophenolate mofetil, cyclophosphamide, sirolimus, everolimus, cyclosporine, basiliximab, etanercept, golimumab, cantuzumab, tocilizumab, conatumumab, corticosteroids, or intravenous immunoglobulin (IVIG). Chronic endometritis diagnosed by endometrial biopsy. Uterine anomalies, uterine fibroids, endometrial polyps, or intrauterine adhesions. Active infections including HIV, hepatitis B, hepatitis C, or other active viral diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live Births . Timepoint: Evaluation of the Effect of Tacrolimus on Recurrent Pregnancy Loss Based on the Number of Live Births 18 month evaluation. Method of measurement: Evaluation of the Effect of Tacrolimus on Recurrent Pregnancy Loss Based on the Number of Live Births. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSomayyeh Shaikhalian Zafarghandi
Avicenna Infertility Center Dr. Shariati Street, Yakhchal Street,Tehran,Iran.
Outcome results
None listed