Major depressive disorder. Major depressive disorder, single episode, moderate
Conditions
Interventions
Intervention 1: The intervention group receives capsules containing dried orange blossom (500 mg, twice daily) along with standard antidepressant treatment. Intervention 2: The control group receives
Sponsors
Fasa University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Having major depressive disorder as diagnosed by a specialist physician and based on the DMS-5 criteria Having moderate to severe depression (BDI score greater than or equal to 18) Willingness and consent to participate in the research project (by completing and signing the informed consent form)
Exclusion criteria
Exclusion criteria: Recent use of medications that interact with bergamot, such as SSRIs or MAO inhibitors Recent use of herbal medicines with psychoactive effects History of bipolar disorder or psychosis Substance abuse 6 months before the start of the study Allergies to medicinal plants such as hives, itchy skin, nausea, vomiting, stomach cramps, and stomach pain Becoming pregnant during the study or planning to become pregnant during the study Having chronic diseases such as diabetes, high blood pressure Liver disease and malignant diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression. Timepoint: 0-4-8 weeks. Method of measurement: questionnaire.;DMS-5. Timepoint: 0-4-8 weeks. Method of measurement: Beck Questionar. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarokh Baharluie
Fasa University of Medical Sciences
Outcome results
None listed