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Effect of Electrical Brain Stimulation on Depression, Anxiety, and Alcohol Craving After Withdrawal

Investigating the Effect of Cranial electrotherapy stimulation on Anxiety, Depression, and Alcohol Craving in patients after alcohol withdrawal

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250527065927N1
Enrollment
24
Registered
2026-02-25
Start date
2026-01-21
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol craving. Z13.3Special screening examination for mental and behavioural disorders

Interventions

Intervention 1: Control group: 12 alcohol-dependent individuals who receive only usual care (gabapentin 300 mg every 8 hours) and:Do not receive transcranial electrical stimulation (tES/tDCS).Like the

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adults (aged 18 and above) with a diagnosis of alcohol use disorder based on DSM-5 criteria. Having a score above the threshold on scales assessing anxiety, depression, and alcohol craving Ability to understand and sign an informed consent form Absence of other severe neurological or psychiatric disorders (except anxiety and depression) No brain lesions, seizures, or history of brain surgery The patient does not use drugs or any opioid or amphetamine compounds or stimulants (smoking is not prohibited).

Exclusion criteria

Exclusion criteria: Presence of medical conditions that are contraindicated for the use of CES, such as severe heart disease, uncontrolled diabetes, etc. Having implanted electronic devices, such as a pacemaker or hearing amplifier The presence of metal embedded in or near the brain Taking medications that interfere with CES, such as anticoagulants Having severe cognitive impairment or inability to understand instructions Being pregnant or breastfeeding in women Withdrawal from participation in the study at any stage of the research A history of seizures or any brain disease Taking any psychiatric medication except gabapentin Use of any substance other than cigarettes

Design outcomes

Primary

MeasureTime frame
The level of temptation to drink alcohol, measured by the Franken Craving Questionnaire. Timepoint: 1. Before the intervention 2. After 4 weeks of intervention. Method of measurement: Patients completed the Franken Craving Questionnaire twice (before and after 4 weeks of intervention).

Secondary

MeasureTime frame
Depression: Hamilton Depression Rating Scale (HDRS) score. Timepoint: Before and after 4 weeks of intervention. Method of measurement: Measurement: Hamilton Depression Rating Scale (HDRS) as an interview by a psychiatrist.;Anxiety questionnaire score (e.g. HADS or BAI). Timepoint: Before and after 4 weeks of intervention. Method of measurement: Anxiety assessment with a standard questionnaire at two points in time.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Rahmani Meybodi

Shahid Beheshti University of Medical Sciences

Dr.mina.rahmani1369@gmail.com+98 21 2614 9087

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026