postoperative nausea and vomiting following spinal cesarean delivery. Delivery by elective caesarean section
Conditions
Interventions
Intervention 1: Intervention Group: Patients in this group will receive 20 mg/kg of magnesium sulfate diluted in 100 mL of normal saline over 20 minutes prior to spinal anesthesia. This will be follow
Sponsors
Karaj University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Elective cesarean section RIP2 singleton pregnancy age = 18 years gestational age between 38 and 42 weeks ASA class II BMI less than 30 informed consent obtained no allergy to magnesium sulfate no history of nausea and vomiting during pregnancy."
Exclusion criteria
Exclusion criteria: history of PONV (postoperative nausea and vomiting) history of motion sickness severe nausea and vomiting during pregnancy history of hyperemesis gravidarum severe nausea and vomiting during spinal anesthesia that could not be adequately controlled contraindications to magnesium sulfate administration (including myasthenia gravis, history of hypersensitivity, hypermagnesemia.. presence of liver disease or other end-organ dysfunction twin or complicated pregnancy obesity (BMI > 30 kg/m²) contraindication to regional anesthesia or allergy to local anesthetic history of antidepressant use gastrointestinal disorders any surgery requiring general anesthesia for any reason massive hemorrhage (blood loss > 1 liter) such as placenta previa or placenta accreta duration of cesarean section exceeding 45 minute intraoperative hemodynamic instability such as severe hypotension or significant arrhythmias (e.g., profound bradycardia preeclampsia, eclampsia use of antiemetic medications within the past 24 hours complicated cesarean section for any reason birth of a neonate with an Apgar score < 7, or neonate requiring admission to NICU.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency and incidence of nausea and vomit. Timepoint: From the time of anesthesia, every 5 minutes during the operation, and then every 15 minutes for up to 3 hours postoperatively in the recovery room. Method of measurement: Observation, interview, and checklist.;Frequency and incidence of vomit. Timepoint: From the time of anesthesia, every 5 minutes during the operation, and then every 15 minutes for up to 3 hours postoperatively in the recovery room. Method of measurement: Observation, interview, and checklist. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of shivering. Timepoint: From the time of anesthesia, every 5 minutes during the operation, and then every 15 minutes for up to 3 hours postoperatively in the recovery room. Method of measurement: Through observation and interview based on the Bedside Shivering Assessment Scale (BSAS).;Postoperative pain. Timepoint: The patient's first complaint of pain following spinal anesthesia. Method of measurement: Through observation and interview based on Visual Analogue Scale (VAS).;Vital signs including blood pressure, heart rate, and oxygen saturation. Timepoint: From the time of anesthesia, every 5 minutes during the operation, and then every 15 minutes for up to 3 hours postoperatively in the recovery room. Method of measurement: Monitoring device including a blood pressure monitor and pulse oximeter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactzahra mohammadi
Karaj University of Medical Sciences
Outcome results
None listed