Comparative Analgesic Effects of Peripheral and Central Pain Relievers in Immediate and Delayed Dental Implant Surgeries

Comparing the analgesic effect of NSAID analgesic drugs with peripheral effect and analgesic with central effect in immediate and delayed implant surgeries? A Randomized Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250526065898N1

Enrollment

120

Registered

2025-08-19

Start date

2025-08-23

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental implant placement in immediate and delayed implant surgeries for postoperative pain management. Other specified disorders of teeth and supporting structures

Interventions

Intervention 1: Intervention group: The immediate implant placement protocol commences with comprehensive preoperative assessment utilizing CBCT imaging to evaluate bone quality (based on entry criter

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients referring to the Implant Department of Mashhad Dental School Age range between 20 and 50 years with willingness to participate in the study Suitable bone quantity and quality for implant placement, with minimum bone width of 7 mm and height of 13 mm according to CBCT radiographic examinations Full informed consent for participation in the study

Exclusion criteria

Exclusion criteria: History of drug abuse or current substance addiction. Use of medications that may interfere with bone osseointegration. Presence of systemic diseases (such as diabetes, cardiovascular disease, hypertension, liver or kidney diseases, immune deficiency, or chronic inflammatory disease). Lack of willingness to cooperate or inability/unwillingness to provide informed consent. Any medical condition or situation (as determined by the investigator) that could compromise patient safety or affect the efficacy of interventions (e.g., known allergy to the study drugs, history of peptic ulcer or gastrointestinal bleeding, history of asthma or hypersensitivity to NSAIDs, current use of anticoagulants or certain antidepressants). Pregnancy or breastfeeding

Design outcomes

Primary

Measure	Time frame
The primary outcome variable in this study is the severity of pain after dental implant surgery, which will be measured subjectively. Timepoint: Patients' pain intensity is measured and recorded at a point in time one week after implant surgery. Method of measurement: Pain is assessed using the Visual Analogue Scale (VAS). This standard method involves a 10-centimeter line, with one end marked as "no pain" (zero) and the other as "worst pain imaginable" (ten). The patient is asked to indicate their level of pain by placing a mark on the line. The distance from the "no pain" end to the patient’s mark is measured with a ruler, providing a pain score between 0 and 10.	—

Measure

Time frame

The primary outcome variable in this study is the severity of pain after dental implant surgery, which will be measured subjectively. Timepoint: Patients' pain intensity is measured and recorded at a point in time one week after implant surgery. Method of measurement: Pain is assessed using the Visual Analogue Scale (VAS). This standard method involves a 10-centimeter line, with one end marked as "no pain" (zero) and the other as "worst pain imaginable" (ten). The patient is asked to indicate their level of pain by placing a mark on the line. The distance from the "no pain" end to the patient’s mark is measured with a ruler, providing a pain score between 0 and 10.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarid Shiezadeh

Mashhad University of Medical Sciences

fshd1365@gmail.com+98 51 3806 7100

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026