Chemical pneumonitis induced by sulfur mustard gas. Bronchitis and pneumonitis due to chemicals, gases, fumes and vapors
Conditions
Interventions
Intervention 1: Intervention group: Patients in the intervention group receive 7% sodium chloride solution (hypertonic saline) through an Omron NE-U22 mesh nebulizer device. The treatment protocol inc
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Chemical warfare veteran with documented exposure to sulfur mustard gas Medically confirmed pulmonary complications due to sulfur mustard exposure Moderate to severe degree of pulmonary involvement Age between 40-70 years No acute respiratory infection in the past 4 weeks No changes in baseline medications in the past month Willingness to participate and sign informed consent
Exclusion criteria
Exclusion criteria: Severe asthma or bronchiectasis unrelated to chemical injury Class III or IV heart failure according to New York Heart Association criteria Renal failure Advanced liver disease Uncontrolled hypertension History of allergic reaction to hypertonic sodium chloride (7%) Tobacco/waterpipe use within the past 6 months Regular alcohol consumption Severe cognitive impairment Current ICU admission or requirement for mechanical ventilation Unwillingness to participate or sign informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Forced Expiratory Volume in 1 second (FEV1). Timepoint: Weeks 0, 4, and 8 post-intervention. Method of measurement: Standard spirometry using calibrated equipment.;Respiratory Quality of Life Questionnaire Total Score. Timepoint: Weeks 0 and 8 post-intervention. Method of measurement: St. George Respiratory Quality of Life Questionnaire.;Serum C-reactive protein (CRP) level. Timepoint: Weeks 0 and 8 post-intervention. Method of measurement: ELISA using standardized kits. | — |
Secondary
| Measure | Time frame |
|---|---|
| Forced Vital Capacity (FVC). Timepoint: Weeks 0, 4, and 8 after intervention. Method of measurement: Standard spirometry using calibrated equipment.;Peak Expiratory Flow (PEF). Timepoint: Weeks 0, 4, and 8 after intervention. Method of measurement: Spirometry.;Frequency of coughing episodes. Timepoint: Weeks 0, 4, and 8 after intervention. Method of measurement: Patient-reported daily diary (visual analog scale).;Sputum production volume. Timepoint: Days 1 and 3, weeks 0, 4, and 8 after intervention. Method of measurement: Graded container measurement (morning collection).;Dyspnea. Timepoint: Weeks 0 and 8 after intervention. Method of measurement: Revised Medical Research Council Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMansoureh Molaei
Bagheiat-allah University of Medical Sciences
Outcome results
None listed