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Comparison of the fibrinolytic effects of two drugs: Fibrinolysin ointment and ozone oil in the treatment of deep second-degree burns

Comparison of the fibrinolytic effect of two drugs: fibrinolysin ointment and ozone oil in the treatment of deep second-degree burns

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250524065868N1
Enrollment
120
Registered
2025-07-26
Start date
2025-08-23
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

deep second degree burns. Burn of second degree, body region unspecified

Interventions

Intervention 1: Control group: Fibrinolysin ointment (product of Vestagen Pars Company) is applied to a portion of the burn site and bandaged. Changing the dressing and examining the burn wound contin

Sponsors

Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with deep second-degree burns who have been referred to the burn clinic of Shahid Rajaee Hospital in Qazvin. Burns of known depth and confirmed by a specialist (presence of a dry and thick, dark red or waxy white appearance) Burns in an area where it is possible to use two types of treatment (fibrinolysin ointment and ozone oil) simultaneously in two different parts. Written consent of the patient to participate in the study and acceptance of treatment conditions and periodic follow-ups

Exclusion criteria

Exclusion criteria: Patients with third-degree burns or very superficial burns (superficial second-degree or first-degree) Presence of active infection at the burn site at the time of study entry Patients with chronic skin diseases or chronic inflammatory disorders that can affect the healing process Previous use of fibrinolytic therapies or other specific treatments for burns at the study site Known sensitivity or allergy to any of the ingredients in fibrinolysin ointment or ozone oil Patients with severe systemic conditions or comorbidities that may affect burn healing (e.g., uncontrolled diabetes, renal or hepatic failure) Patient's inability or unwillingness to follow up on dressings and assess wounds regularly

Design outcomes

Primary

MeasureTime frame
Burn treatment. Timepoint: Every other day for two weeks. Method of measurement: Changing the dressing and examining the burn wound by taking a picture of the wound and uploading it to the following site for color analysis: http://mkweb.bcgcsc.ca/color-summarizer/?analyze.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Farzaneh

Qazvin University of Medical Sciences

amir_farzaneh1360@yahoo.com+98 28 3333 6001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026