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Comparing the risk of post-surgery delirium in older adults: sevoflurane vs propofol anesthesia

The comparative analysis of post-operative delirium incidence: sevoflurane vs propofol in geriatric patients under general anaesthesia

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250524065864N1
Enrollment
200
Registered
2025-05-27
Start date
2024-12-05
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-operative delirium (POD) is a common and serious complication that occurs after surgery, particularly in older adults. It is characterized by an acute and fluctuating disturbance in attention, awareness, and cognition, typically arising within the first few days following anesthesia and surgery. POD can manifest as confusion, disorientation, memory disturbances, hallucinations, or agitation, and may vary in intensity and duration. It is associated with increased morbidity, prolonged hospita

Interventions

Intervention 1: Intervention group: Group A received sevoflurane-based anesthesia, while Group B received propofol-based anesthesia. All participants were induced with intravenous propofol (1–2 mg/kg)

Sponsors

Faisalabad medical university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 90 Years

Inclusion criteria

Inclusion criteria: Both gender 60-90 Patients undergoing for Mild to moderate risk elective surgery American society of Anesthesiology (ASA) I-III

Exclusion criteria

Exclusion criteria: Patient with preoperative delirium History of dementia Psychiatric disease like schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis Hepatic or renal dysfunction Requirement for postoperative mechanical ventilation Allergy to any of the study drugs History of surgery within the recent six months

Design outcomes

Primary

MeasureTime frame
Post Operative Delirium. Timepoint: During the first seven post-operative days, delirium will be assessed twice each day, that is, between 8–10 am and 6–8 pm, by using CAM. Delirium will be assessed as per operational definition. All the information will be recorded on performa by myself. Method of measurement: Confusion Assessment Method.

Secondary

MeasureTime frame
Reduce hospital stay and better outcomes. Timepoint: During the first seven post-operative days, delirium will be assessed twice each day, that is, between 8–10 am and 6–8 pm, by using CAM. Method of measurement: Confusion Assessment Method (CAM).

Countries

Pakistan

Contacts

Public ContactDr Humaira Ahmad

Allied Hospital faisalabad

Humaira_ahmad21@hotmail.com+92 333 5824895

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026