Polycystic ovarian syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Women with polycystic ovary syndrome taking astaxanthin extract from the algae Haematococcus pluvialis. Based on previous clinical studies demonstrating efficacy and safety in this the
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Definitive diagnosis of PCOS based on the Rotterdam criteria, which includes at least two of the three criteria: oligo- or anovulation, clinical or biochemical signs of hyperandrogenism, and polycystic ovarian morphology on ultrasound. No use of hormonal drugs and antioxidant supplements in the past three months , being under IVF treatment and having written consent to participate in the study
Exclusion criteria
Exclusion criteria: Acute inflammatory diseases with CRP greater than 10 mg/L, type 1 or 2 diabetes with fasting blood sugar greater than 126 mg/dL, and autoimmune diseases. Concomitant use of antioxidant supplements, pregnancy, or breastfeeding History of cancer, severe liver or kidney disease, and use of anti-inflammatory drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory factors IL18, IL1b and NLRP3; Expression of selected microRNAs; Expression of selected long non-coding mRNA in female oocytes. Timepoint: Before the intervention and 12 weeks after the intervention. Method of measurement: Biochemical and laboratory methods. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNavid Abedpoor
Islamic Azad University
Outcome results
None listed