Knee osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: 1800 mg artichoke leaf extract as 4 tablets per day for 12 weeks. Intervention 2: Control group: 1800 mg placebo containing corn starch as 4 tablets per day for 12
Sponsors
Zabol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Willingness and ability to collaborate on project aged 40-70 years from both sex Confirmation of bilateral primary knee osteoarthritis Body mass index between 25-35 kg/m2 Consumption of glucoseamine, chondroitin sulfate supplements and acetaminophen as anti-pain drug
Exclusion criteria
Exclusion criteria: Alcohol consumption Smoking Pregnant and lactating women Secondary osteoarthritis Having an active synovitis Having a history of knee injection within 6 months before intervention Neurological disorder that affects movement, muscle control and balance Affected by cardiovascular disease, renal failure, diabetes mellitus, liver dysfunction, cancer; affected by infectious or inflammatory disease or recent surgery Consumption of Furosemide, Probenecid, Anticoagulants, Anticonvulsant drugs, Sulphonamides, Methotrexate, Lithium salts and muscle relaxants currently or within 3 months before intervention Consumption of fish oil supplement or other antioxidant supplements currently or within 3 months before intervention History of allergy to artichoke family plants and their products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: WOMAC questionnaire.;Joint stiffness. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: WOMAC questionnaire.;Disability. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: WOMAC questionnaire.;Oxidative markers. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Total antioxidant capacity (TAC) by using spectrophotometry, MDA by using thiobarbituric acid, Total oxidant capacity by using ELISA kit.;Inflammatory markers. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Serum levels of TNF-a? IL-1ß and IL-6 by using ELISA kits. | — |
Secondary
| Measure | Time frame |
|---|---|
| Anthropometric measurements. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: Weight and Height by using Seca scale and stadiometer respectively, waist circumference by using tape measure, Body mass index (BMI) will be calculated as weight in kilograms divided by the square of height in meters.;Energy and macro-nutrients intake. Timepoint: Baseline and 12 weeks after intervention. Method of measurement: 3-day 24 hours food recall. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarshad Amirkhizi
Zabol University of Medical Sciences
Outcome results
None listed