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Effects of coenzyme Q10 on linezolid related side effects

Evaluation of the effects of coenzyme Q10 administration on the prevention of linezolid-induced complications in the intensive care unit: a randomized, double-blind, controlled study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250515065754N1
Enrollment
100
Registered
2025-06-20
Start date
2024-06-21
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thrombocytopenia. Thrombocytopenia, unspecified

Interventions

Intervention 1: Intervention group: Patients will receive 100 micrograms of coenzyme Q10 daily for a duration of 10 days. Intervention 2: Control group: Patients will receive one placebo pill each day

Sponsors

Kermanshah University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Intensive care unit stay for for at least 72 hours Patients receiving linezolid Patients who sign an informed consent form Documented or possible staphylococcal infections

Exclusion criteria

Exclusion criteria: Incomplete information in the file Lack of consent of the patient or his/her companions to participate in the study Treatment with the drug Coenzyme Q10

Design outcomes

Primary

MeasureTime frame
Platelet Count. Timepoint: Day 7, 10. Method of measurement: Complete Blood Count (CBC).;Serum sodium concentration. Timepoint: Day 10. Method of measurement: Lab data.

Secondary

MeasureTime frame
Incidence of gastrointestinal, cardiovascular, and metabolic complications in the intervention group compared to the control group. Timepoint: Day 10. Method of measurement: The Division of AIDS (DAIDS) Table for Grading the Severity of Adult and Pediatric Adverse Event.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactForoud Shahbazi

Kermanshah University of Medical Sciences

Foroud08@gmail.com+98 83 3839 5885

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026