Effectiveness of fibroblast-derived extracellular vesicles to improve skin wrinkles

Studying the effectiveness of allogenic human fibroblast-derived extracellular vesicles compared to placebo to improve collagen production and the appearance of skin wrinkles in people with skin wrinkles on their face or hands

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250515065751N1

Enrollment

Registered

2025-07-19

Start date

2025-12-21

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wrinkles. Other specified disorders of the skin and subcutaneous tissue

Interventions

Intervention 1: Intervention group: In each participant, two skin areas with visible wrinkles either on the face or the back of the hand will be selected. One of these areas will receive the intervent

Eligibility

Sex/Gender

All

Age

30 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age 30-50 Willing to receive antiaging treatment on face or back of the hand area Having wrinkles on face or back of their hands

Exclusion criteria

Exclusion criteria: History of skin diseases or skin allergies Diagnosis of any type of skin cancer Presence of a specific condition (such as diabetes) that affects skin healing ability Use of blood-thinning medications Use of immunosuppressive drugs Unrealistic expectations Pregnancy or breastfeeding Occurrence of a reaction at the injection site

Design outcomes

Primary

Measure	Time frame
Wrinkles appearance. Timepoint: Weeks 4, 12, 24. Method of measurement: questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasume Hoseininejad

Mashhad University of Medical Sciences

hoseininejadmd94@gmail.com+98 51 3846 2601

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026