Contrast-induced nephropathy following coronary interventions. Nephropathy induced by other drugs, medicaments and biological substances
Conditions
Interventions
Intervention 1: Intervention group: Patients in the ranolazine intervention group will receive 1000 mg of ranolazine every 12 hours, starting 24 hours before the procedure and continuing for 48 hours
Sponsors
Qazvin University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: chronic kidney disfunction with GFR between 30 and 60 Candidates for coronary interventions based on the attending physician's opinion above 18 years old consent to participate in the study
Exclusion criteria
Exclusion criteria: History of sensitivity or allergy to ranolazine or contrast Presence of severe liver failure and cirrhosis Severe heart failure, grade 4, or (EF = 30%) Severe renal failure (GFR = 30) or a history of dialysis Presence of an active infection or malignancy Use of medications that have been reported to potentially affect the incidence of nephropathy in studies Concurrent use of class Ia antiarrhythmic drugs (e.g., quinidine, procainamide, disopyramide) or class III (e.g., sotalol, ibutilide, amiodarone, dronedarone), which may interact with ranolazine pregnancy Refusal to participate in the study, lack of cooperation, and non-compliance with treatment protocols Willingness to withdraw from the study for any reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of contrast-induced nephropathy. Timepoint: Measurement of blood creatinine levels 24 hours before and 48 hours after the procedure. Method of measurement: Blood sample collected from the patient.;Difference in blood creatinine levels before and after the procedure. Timepoint: Measurement of blood creatinine levels 24 hours before and 48 hours after the procedure. Method of measurement: Blood sample collected from the patient.;Need for dialysis. Timepoint: During hospitalization. Method of measurement: Dialysis performed based on the attending physician's recommendation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications arising from the procedure. Timepoint: during Hospitalization. Method of measurement: Complications arising from coronary interventions, such as bleeding, infection, hematoma, arrhythmia, and more.;Death. Timepoint: During Hospitalization. Method of measurement: Patient death following the procedure. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Motamedi Rad
Qazvin University of Medical Sciences
Outcome results
None listed