Persistent corneal epithelial defect.
Conditions
Interventions
Intervention 1: Intervention group: using insulin drop (1.25cc regular insulin combined with 3.75cc of artificial tear-Lacrivision ) every 6 hour in the affected eye. Intervention 2: Control group: ar
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age of at least 18 years old Corneal epithelial defect without any change in size, despite adequate treatment over past two weeks , ultimately necessitating amniotic membrane graft
Exclusion criteria
Exclusion criteria: Any sign of active corneal infiltration/keratitis or vision-threatening situations Non-evaluable corneal epithelial defect size due to large tarsorrhaphy Lack of patient consent to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal epithelial defect size. Timepoint: Measurement of corneal epithelial defect size at baseline (before initiation of the intervention) and on days 3, 6, 9, 12, and 24 after administration of insulin eye drops. Method of measurement: Using a slit lamp after staining with fluorescein paper and cobalt blue light, reporting in mm2. | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual acuity. Timepoint: Measurement of Visual acuity at baseline (before initiation of the intervention) and on days 3, 6, 9, 12, and 24 after administration of eye drops. Method of measurement: Snellen chart. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSalar Bahrami
Shahid Beheshti University of Medical Sciences
Outcome results
None listed