Effect of Exercise and Cinnamon on Diabetic Women

The Protective Effect of Different Intensities of Aerobic Exercise Combined with Resistance Training and Cinnamon Against Oxidative Stress in Women with Diabetes via the TLR4/MyD88/NF-?B Signaling Pathway

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250513065713N1

Enrollment

Registered

2025-06-02

Start date

2025-06-15

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention Group 1 (Control): Participants will take placebo capsules twice daily for eight weeks. Intervention 2: Intervention Group 2 (Moderate-Intensity Aerobic+Resistance Trainin

Eligibility

Sex/Gender

Female

Age

35 Years to 50 Years

Inclusion criteria

Inclusion criteria: Diagnosis of type 2 diabetes, defined as having more than two fasting glucose measurements above 126 mg/dL and HbA1c levels higher than 5.6%, under medical supervision at the time of the study Age between 35 and 50 years No musculoskeletal disorders Sedentary lifestyle (less than one hour of physical activity per week) Willingness to participate in the study No cardiovascular diseases No metabolic conditions limiting physical activity No hypertension No history of regular physical activity in the past six months Not receiving insulin therapy

Exclusion criteria

Exclusion criteria: Use of antihypertensive and lipid-lowering medications Severe diabetes complications (e.g., proliferative diabetic retinopathy, stage 3 or overt nephropathy, diabetic ketoacidosis, or severe diabetic neuropathy) Hereditary glucose and galactose malabsorption or renal glycosuria

Design outcomes

Primary

Measure	Time frame
The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).;The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of myeloid differentiation primary response 88 (MyD88). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).;The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of toll-like receptor 4 (TLR4). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).;The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of heme oxygenase-1 (HO-1). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).;The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of nuclear factor erythroid 2–related factor 2 (Nrf2). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).	—

Measure

Time frame

The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).;The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of myeloid differentiation primary response 88 (MyD88). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).;The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of toll-like receptor 4 (TLR4). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).;The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of heme oxygenase-1 (HO-1). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).;The effect of different intensities of aerobic exercise combined with resistance training and cinnamon on the expression of nuclear factor erythroid 2–related factor 2 (Nrf2). Timepoint: Two days before and after the intervention. Method of measurement: Biochemical and laboratory methods (RT-PCR).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmad Abdi

Islamic Azad University

a.abdi@iauamol.ac.ir+98 11 4321 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026