Breast Cancer. Malignant neoplasm of breast
Conditions
Interventions
Intervention 1: Intervention group: Women with locally invasive stage II or III breast cancer that is Hormone receptor positive (ER/PR) and HER-2 negative, or with pathological axillary lymph node met
Sponsors
Kashan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Women with ER, PR positive, HER2 negative invasive breast cancer or pathological axillary lymph node metastasis or T3 or T4 primary tumor below 18 years old Karnofsky functional status index of at least 80 Not pregnant or breastfeeding Have a disproportionate TUMOR TO BREAST RATIO
Exclusion criteria
Exclusion criteria: Patients if there was clinical or imaging evidence of distant metastases prior to study entry History of cancer in the past 5 years Pre-existing bone disease that may require targeted bone therapy Have a serum creatinine concentration greater than 1.5 times the upper limit of normal Any problems with your mouth or teeth Current or recent (past year) use of bisphosphonates
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological Complete Response. Timepoint: Two weeks after completing chemotherapy. Method of measurement: It is a histological examination after completion of chemotherapy. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactVahid Abolhasani
Kashan University of Medical Sciences
Outcome results
None listed