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The effect of intravenous magnesium sulfate injection on the incidence of contrast nephropathy in patients undergoing angiography.

Study of the effect of intravenous magnesium sulfate injection on the incidence of contrast nephropathy in patients undergoing diagnostic coronary angiography. A randomized clinical trial study, open-label

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250507065634N9
Enrollment
150
Registered
2025-11-11
Start date
2026-01-05
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contrast Nephropathy. Nephropathy induced by other drugs, medicaments and biological substances

Interventions

Intervention 1: Control group: Seventy-five eligible patients hospitalized at Shariati Hospital in Tehran were randomly assigned to the control group. According to the standard protocol for prevention

Sponsors

Dr. Shariati Educational, Research and Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age over 18 years No history of magnesium supplement use

Exclusion criteria

Exclusion criteria: Patients with severe renal insufficiency (estimated glomerular filtration rate based on the CKD-EPI formula >30 mL/min/1.73 m2) or history of dialysis Severe liver failure Having active cancer Anemia with a hemoglobin level of less than 10 Age over 75 years Heart failure with an ejection fraction of less than 30% Mean arterial blood pressure of less than 70 before receiving contrast Magnesium levels outside the normal range History of sensitivity to contrast medium

Design outcomes

Primary

MeasureTime frame
Contrast-Induced Nephropathy. Timepoint: Before coronary artery catheterization and 48-72 hours after coronary artery catheterization. Method of measurement: An increase of more than 0.3 mg/dL in creatinine level or a 25-50% increase in creatinine in patients within two to three days after coronary artery catheterization (based on KDIGO guidelines).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarnaz Tavakoli

Tehran University of Medical Sciences

farnaztavakkoli@gmail.com+98 912 481 2899

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026