Condition 1: Recurrent Pregnancy Loss. Condition 2: Spontaneous abortion. Pregnancy care for patient with recurrent pregnancy loss Spontaneous abortion
Conditions
Interventions
Intervention 1: Control group: They will receive oral vitamin D3 1000 units daily after a positive pregnancy test and confirmation of intrauterine pregnancy with serial pregnancy tests or vaginal ultr
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Women between the ages of 18 and 40 Women who are trying to conceive Women with a history of at least two consecutive first-trimester miscarriages of unknown origin, with normal parental karyotype, absence of uterine abnormalities associated with recurrent miscarriage Normal serum vitamin D levels (above 30) and less than 100 Consent to participate in the study
Exclusion criteria
Exclusion criteria: Pregnancy at the time of study entry Normal pregnancy since last miscarriage Antiphospholipid syndrome with persistently positive APL antibodies and the presence of clinical conditions of APS based on Myakis criteria Known contraindications for the use of hydroxychloroquine or vitamin D Other chronic diseases History of epilepsy or psychotic disorders History of recent use of hydroxychloroquine or vitamin D in the past two months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of ongoing pregnancy. Timepoint: Week 20 onwards. Method of measurement: Ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Repeated miscarriage. Timepoint: Before week 20. Method of measurement: Fetal loss before 20 weeks with Ultrasound.;Gestational age at the time of miscarriage. Timepoint: Number of weeks of pregnancy. Method of measurement: Ultrasound.;Fetal abnormalities. Timepoint: Weeks 6-8, 11-13, 18-22 of pregnancy. Method of measurement: Ultrasound. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShaghayegh Jahantigh
Mashhad University of Medical Sciences
Outcome results
None listed