Skip to content

Comparison of the effects of exmedetomidine and ketamine infusion on transcranial motor evoked potentials and somatosensory evoked potentials

Comparison of the effects of dexmedetomidine and ketamine infusion on transcranial motor evoked potentials and somatosensory evoked potentials in adult patients undergoing elective spinal surgery under general intravenous anesthesia.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250507065634N11
Enrollment
40
Registered
2025-11-20
Start date
2025-12-06
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spine surgery. Injury of nerve root of thoracic spine, subsequent encounter

Interventions

Intervention 1: Control group: Twenty patients who met the inclusion criteria and were hospitalized at Shariati Hospital in Tehran were randomly assigned to the dexmedetomidine group. These patients r

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with ASA Class 1-3 Patients with Motor force > 4

Exclusion criteria

Exclusion criteria: Cardiac conduction diseases and 2nd and 3rd degree heart blocks Unstable cardiac arrhythmias Uncontrolled hypertension Advanced liver and kidney disease Various neuromuscular and psychiatric diseases Obese patients with BMI>35 Patients with ASA Class 4 Patients with coagulopathy and anemia with Hb<10g/dl Patients with a history of long-term and chronic alcohol consumption Patients with contraindications to MEP monitoring (including: cortical lesion, intracranial electrode, cardiac pacemaker, vascular clips, epilepsy) Acute spinal cord injury

Design outcomes

Primary

MeasureTime frame
Motor evoked potential(MEP). Timepoint: At the beginning of surgery, after 30 minutes, after 60 minutes, end of surgery. Method of measurement: Neurophysiological monitoring system.;Sensory evoked potential (SSEP). Timepoint: At the beginning of surgery, after 30 minutes, after 60 minutes, end of surgery. Method of measurement: Neurophysiological monitoring system.;Postoperative pain intensity. Timepoint: At PACU admission, PACU discharge, and 24 hours postoperatively. Method of measurement: Numerical Rating Scale (NRS 0–10).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAsal Vahidnia

Tehran University of Medical Sciences

asalvahidnia90@gmail.com+98 991 200 1620

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026