Abscess of lung and mediastinum. Abscess of lung and mediastinum
Conditions
Interventions
Intervention 1: Intervention group: In patients in the intervention group, plasminogen (TPA), produced by Samen Pharmaceutical Company, will be injected into the pleural space at a dose of 0.1 mg per
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Presence of pneumonia Pleural effusion
Exclusion criteria
Exclusion criteria: Evidence of bleeding or bleeding disorder Pneumothorax Persistent leak from chest tube site Evidence of bronchopleural fistula Evidence of fibrinous septa and loculation on ultrasound or pleural paracentesis results with any of the following: lactate dehydrogenase greater than 1000, glucose less than 40, Gram stain fails to identify organism, frank pus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recovery. Timepoint: After the intervention is completed. Method of measurement: Monitoring vital signs with a vital signs monitor, thermometer, blood pressure monitor, and pulse oximeter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythrocyte sedimentation rate. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Erythrocyte sedimentation rate test.;CRP (C-reactive protein) test. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: It is performed using nephelometric or turbidometric methods in automated laboratory devices.;CBC diff test (complete blood count with differential). Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Blood cell counting is performed using automated machines.;Need for thoracotomy (open surgery) orminimally invasive surgery. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Imaging.;Fever. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Thermometer.;Respiratory distress. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Stopwatch.;Oxygen level. Timepoint: Before the intervention begins and after the intervention ends. Method of measurement: Pulse oximetry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisan Omidvar
Mashhad University of Medical Sciences
Outcome results
None listed