The Effect of Physical Activity and Caloric Restriction on Inflammatory Markers and Blood Glucose in Overweight and Obese Women

The Effects of Different Doses of Combined Exercise Training with Caloric Restriction on Levels of Endocan and Interleukin-6 in Overweight and Obese Sedentary Women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250505065611N1

Enrollment

Registered

2025-07-06

Start date

2025-05-18

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight and obesity. Overweight and obesity

Interventions

Intervention 1: Intervention Group 1: Two exercise sessions per week + caloric restriction (a daily deficit of 360 kcal). In addition, each exercise session will involve an energy expenditure of appro

Eligibility

Sex/Gender

Female

Age

19 Years to 50 Years

Inclusion criteria

Inclusion criteria: Body Mass Index (BMI) between 27 and 35 No use of specific medications No underlying diseases such as diabetes

Exclusion criteria

Exclusion criteria: Physical problems that prevent engagement in physical activity Under medical treatment or following a specific diet

Design outcomes

Primary

Measure	Time frame
Endocan. Timepoint: Endocan levels are measured through blood tests one week before the intervention begins and 60 days after the intervention period ends. Method of measurement: Endocan levels are measured through blood tests using ELISA kits.;Interleukin-6. Timepoint: Interleukin-6 levels are measured through blood tests one week before the intervention begins and 60 days after the intervention period ends. Method of measurement: Interleukin-6 levels are measured through blood tests using ELISA kits.	—

Measure

Time frame

Endocan. Timepoint: Endocan levels are measured through blood tests one week before the intervention begins and 60 days after the intervention period ends. Method of measurement: Endocan levels are measured through blood tests using ELISA kits.;Interleukin-6. Timepoint: Interleukin-6 levels are measured through blood tests one week before the intervention begins and 60 days after the intervention period ends. Method of measurement: Interleukin-6 levels are measured through blood tests using ELISA kits.

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Secondary

Measure	Time frame
Weight. Timepoint: Weight measurement is at the beginning of the study (before the start of the intervention) and 60 days after the start of the intervention. Method of measurement: A scale is used to measure weight.;Body Fat Percentage. Timepoint: Body Fat Percentage is at the beginning of the study (before the start of the intervention) and 60 days after the start of the intervention. Method of measurement: Body fat percentage will be measured using a body composition analyzer (InBody 270).;Muscle mass. Timepoint: Muscle mass is at the beginning of the study (before the start of the intervention) and 60 days after the start of the intervention. Method of measurement: Muscles mass will be measured using a body composition analyzer (InBody 270).;Visceral Fat Levels. Timepoint: Visceral Fat Levels is at the beginning of the study (before the start of the intervention) and 60 days after the start of the intervention. Method of measurement: Visceral Fat Levels will be measured using a body composition analyzer (InBody 270).	—

Measure

Time frame

Weight. Timepoint: Weight measurement is at the beginning of the study (before the start of the intervention) and 60 days after the start of the intervention. Method of measurement: A scale is used to measure weight.;Body Fat Percentage. Timepoint: Body Fat Percentage is at the beginning of the study (before the start of the intervention) and 60 days after the start of the intervention. Method of measurement: Body fat percentage will be measured using a body composition analyzer (InBody 270).;Muscle mass. Timepoint: Muscle mass is at the beginning of the study (before the start of the intervention) and 60 days after the start of the intervention. Method of measurement: Muscles mass will be measured using a body composition analyzer (InBody 270).;Visceral Fat Levels. Timepoint: Visceral Fat Levels is at the beginning of the study (before the start of the intervention) and 60 days after the start of the intervention. Method of measurement: Visceral Fat Levels will be measured using a body composition analyzer (InBody 270).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKatayoun Zamani

Tehran University

Katayoun.zamani@ut.ac.ir+98 21 4612 3722

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026