Skip to content

Comparison of the effect of letrozole and misoprostol and misoprostol alone on pregnancy remnants

Comparison of the effect of letrozole and misoprostol and misoprostol alone on pregnancy remnants

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250505065609N1
Enrollment
100
Registered
2025-09-12
Start date
2025-10-04
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Legal abortion. Termination of pregnancy, affecting fetus and newborn

Interventions

Intervention 1: In the intervention group, patients receive a single oral dose of 20 mg Letrozole, produced by Abureyhan Pharmaceutical Company. Additionally, misoprostol is administered as an adjunct

Sponsors

Sanandaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age over 18 years Gestational age less than 18 weeks confirmed by ultrasound on the first day of the study Candidates for legal and medical abortion Hemoglobin level more than 10 g/L

Exclusion criteria

Exclusion criteria: Patients with severe bleeding requiring emergency curettage Any known allergy to Misoprostol and Letrozole

Design outcomes

Primary

MeasureTime frame
Miscarriage duration. Timepoint: Time points for measuring the rate of miscarriage: Measuring the rate of excretion of pregnancy products at the beginning of the study (24 hours after the start of the intervention) and 4, 8, 12, and 24 hours after the start of misoprostol and letrozole. Method of measurement: the time it takes for the remnants of the pregnancy to start coming out in hours.;Type of abortion (complete, incomplete). Timepoint: Time points for measuring the rate of abortion: Measuring the rate of excretion of pregnancy products at the beginning of the study (24 hours after the start of the intervention) and 4, 8, 12, and 24 hours after the start of misoprostol and letrozole. Method of measurement: observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Zeinab Hemmati

Sanandaj University of Medical Sciences

zeinab_hemati@yahoo.com+98 87 3328 9880

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026