Septic shock. Severe sepsis with septic shock
Conditions
Interventions
Intervention 1: Intervention group: Midodrine 5 mg orally every 12 hours for 7 days (manufactured by Pars behrozan Jam). Intervention 2: Intervention group: Fludrocortisone 0.1 mg orally every 12 hou
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients aged over 18 and under 90 years old. Admission to the Intensive Care Unit (ICU) and treatment for septic shock Patients with a mean arterial pressure (MAP) less than 65 mmHg after receiving antibiotics and initial IV fluid resuscitation of 30 ml/kg.
Exclusion criteria
Exclusion criteria: History of advanced hepatic or renal disease Presence of evidence of left ventricular systolic dysfunction or cardiogenic shock, Serum lactate level greater than 4 mmol/L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure (MAP) with a value equal to or greater than 65 mmHg. Timepoint: B lood pressure (MAP) will be recorded every 4 hours for 24 hours starting from the administration of the first dose. Thereafter, patients will be monitored daily for the next 7 days. Method of measurement: Continuous monitoring in the ICU. | — |
Secondary
| Measure | Time frame |
|---|---|
| Dose of vasopressor drugs administered during the study period. Timepoint: Outcome measurements from the initiation of the intervention up to seven days thereafter on a daily basis. Method of measurement: The dose and duration of vasopressor therapy, including norepinephrine, vasopressin, epinephrine, dopamine, and phenylephrine, will be continuously monitored and accurately recorded based on the patients medical records.;Serum Lactate Clearance. Timepoint: Assessments will be conducted at the beginning of the study (before the intervention), 24 hours after the start of the intervention, on day 3 after the start of the intervention, and on day 7 after the start of the intervention. Method of measurement: Using the ABL800 FLEX Blood Gas Analyzer.;Length of Stay in ICU. Timepoint: From ICU admission until ICU discharge. Method of measurement: Electronic medical records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeied Hadi Saghaleini
Tabriz University of Medical Sciences
Outcome results
None listed