Condition 1: leishmania scar. Condition 2: leishmaniasis scar. Cutaneous leishmaniasis
Conditions
Interventions
Intervention 1: Control group: 3 sessions of subcision with a 28-gauge needle as a treatment for leishmaniasis scar at an interval of one month. Intervention 2: Intervention group1: 3 sessions with
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: persistent leishmania scar for at least one year patient should not have used any therapeutic intervention for at least 6 months
Exclusion criteria
Exclusion criteria: no agreement to do the study pregnancy lactation history of diabetic retinopathy history of any malignancy personal or familial history of colorectal cancer history of familial ovarian or testicular cancer history of eclampsia or preclampsia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy of subcision in treatment of leishmania scar. Timepoint: Subcision use at the beginning of the visit and one and two months later and examining the response to treatment one and three months after the end of the intervention. Method of measurement: recording of changes with digital photography in each session, scoring of scar changes based on the standard scar scoring system called modified Manchester Scar Scale (MSS) according to the proposal table by two blind dermatologists, a score between 5 and 18 is given to the changes of scars, also the evaluation of the patients using a questionnaire that is scored from dissatisfied, relatively satisfied, and completely satisfied, and the data will be analyzed in spss software. | — |
Secondary
| Measure | Time frame |
|---|---|
| Leishmania scar changes following the use of platelet-rich plasma (PRP) and human placenta extract (HPE). Timepoint: Injection 3 times at the beginning of visit and one and two months later and record the changes one and three months after the end of the intervention. Method of measurement: Recording of changes with digital photography in each session, scoring of scar changes based on the standard scar scoring system called modified Manchester Scar Scale (MSS) according to the proposal table by two blind dermatologists, a score between 5 and 18 is given to the changes of scars, also the evaluation of the patients using a questionnaire that is scored from dissatisfied, relatively satisfied, and completely satisfied, and the data will be analyzed in spss software. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAhmadreza Taheri
Mashhad University of Medical Sciences
Outcome results
None listed