Infertility. Female infertility
Conditions
Interventions
Intervention 1: Gonadotropin & Clomiphene Citrate group: Patients in this group receive 100 mg of clomiphene citrate tablets (manufactured by Iran Hormon) daily from cycle days 3 to 7. Starting on day
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
40 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patients who meet at least two of the three Bologna criteria for poor ovarian response: Age =40 years or presence of another risk factor for poor ovarian response History of retrieving 3–4 oocytes with a conventional stimulation protocol Abnormal results for ovarian reserve test (Anti Mullerian Hormones (AMH) 0.5–1.1 ng/mL or Antral Folicular Count (AFC) <5–7)
Exclusion criteria
Exclusion criteria: Body Mass Index >36 kg/m² Age >45 years Presence of severe metabolic or autoimmune diseases (e.g., lupus) or severe endometriosis Partner with severe azoospermia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Oocyte retrieved. Timepoint: 36 hours after ovulation induction. Method of measurement: Embryology Laboratory Assessment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Embryo quality. Timepoint: 3-5 days after the in vitro fertilization. Method of measurement: Qualitative assessment in embryology laboratory.;Estradiol levels. Timepoint: The day of ovulation stimulation. Method of measurement: Elisa assessment.;Embryo quality. Timepoint: A day after ovarian puncture. Method of measurement: Qualitative assessment in embryology laboratory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactVajihe Zamani
Iran University of Medical Sciences
Outcome results
None listed