Sepsis. Other sepsis
Conditions
Interventions
Intervention 1: Intervention group: Colchicine: In addition to standard treatment, this group of patients will receive 1 mg of colchicine orally every 12 hours for 5 days (25 patients). Intervention 2
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Septic patients admitted to the ICU (diagnosed according to Sepsis-3 criteria) Age over 18 years Providing written informed consent Having conditions for enteral nutrition
Exclusion criteria
Exclusion criteria: Pregnant women Individuals with very low body weight (body mass index (BMI) <18.5 kg/m2) Patients requiring frequent blood transfusions Patients with septic shock and those patients who experience unwanted side effects after taking the supplement or placebo will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SOFA Score. Timepoint: Day 1 and Day 5. Method of measurement: Clinical and laboratory parameters including PaO2/FiO2 ratio, platelet count, bilirubin, mean arterial pressure, Glasgow Coma Scale, creatinine, and urine output.;D-dimer. Timepoint: Day 1 and Day 5. Method of measurement: Quantitative immunoassay in plasma via Enzyme-linked immunosorbent assay (ELISA).;Fibrinogen. Timepoint: Day 1 and Day 5. Method of measurement: Immunoturbidimetric assay on clinical chemistry analyzers.;PAI_1. Timepoint: Day 1 and Day 5. Method of measurement: Sandwich ELISA assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Kiumarth Amini
Hamedan University of Medical Sciences
Outcome results
None listed