Chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease with (acute) exacerbation
Conditions
Interventions
Intervention group: Caffeine tablets 200 mg orally every 12 hours for 5 days.
Sponsors
Alborz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: COPD patients who meet the criteria for COPD exacerbation (presence of any of the symptoms of worsening shortness of breath, increased sputum volume, increased sputum viscosity) COPD exacerbation patient who requires NIV during an attack Absence of contraindications to NIV placement (trauma or facial deformity, severe decreased level of consciousness, abundant pulmonary secretions, high risk of aspiration, cardiorespiratory arrest) Patient consents to participate in the study4 Age 40 to 85 years
Exclusion criteria
Exclusion criteria: 1. Patient over 85 years of age Pregnancy History of caffeine sensitivity Patient unwillingness to participate in the study Decreased level of consciousness Facial or chest deformity Asthma Neuromuscular diseases and chest disorders Pneumothorax Persistent and frequent vomiting Intolerance to NIV for any reason Occurrence of caffeine side effects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in arterial partial pressure of carbon dioxide (PaCO2) from baseline to day 5. Timepoint: Baseline (before intervention) and daily at 8:00 AM for 5 consecutive days. Method of measurement: Measured using a calibrated arterial blood gas analyzer from arterial blood samples. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSomayeh Rezaian
Karaj University of Medical Sciences
Outcome results
None listed