Studying the effect of PRF on outcomes of impacted third molar surgery

Studying the effect of Platelet-Rich Fibrin (PRF) on pain, swelling, and ecchymosis after impacted third molar surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250428065513N1

Enrollment

Registered

2025-11-05

Start date

2025-11-22

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted third molar surgery.

Interventions

Intervention 1: Intervention group: For patients in the intervention group, following anesthesia administration via injection of the local anesthetic 2% Lidocaine, a full-thickness mucoperiosteal flap

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: The patient's impacted third molar may require surgery, as determined by the dentist. ?Aged over 18 years

Exclusion criteria

Exclusion criteria: Coagulation disorders Allergy to the anesthetic lidocaine Use of psychotropic and anticoagulant drugs Pregnancy and breastfeeding

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Third, seventh, and twenty-first days after surgery. Method of measurement: Visual Analogue Scale (VAS).;Swelling. Timepoint: Before the intervention and on the third, seventh, and twenty-first days after surgery. Method of measurement: The numerical value of the swollen area on the face, measured by vertical and horizontal indicators with calipers.;Ecchymosis. Timepoint: Third, seventh, and twenty-first days after surgery. Method of measurement: Skin discoloration caused by blood leaking from blood vessels into the subcutaneous tissues, measured with a caliper.	—

Measure

Time frame

Pain. Timepoint: Third, seventh, and twenty-first days after surgery. Method of measurement: Visual Analogue Scale (VAS).;Swelling. Timepoint: Before the intervention and on the third, seventh, and twenty-first days after surgery. Method of measurement: The numerical value of the swollen area on the face, measured by vertical and horizontal indicators with calipers.;Ecchymosis. Timepoint: Third, seventh, and twenty-first days after surgery. Method of measurement: Skin discoloration caused by blood leaking from blood vessels into the subcutaneous tissues, measured with a caliper.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mehrdad Shahraki

Zahedan University of Medical Sciences

mehrdadsh409@yahoo.com+98 54 3337 2117

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026