Evaluating the effectiveness of a topical herbal product (Myrtus communis L., Lawsonia inermis L., Ziziphus spina-christi) compared to a topical betamethasone ointment on hand eczema

Evaluating the effectiveness of a topical herbal product (Myrtus communis L., Lawsonia inermis L., Ziziphus spina-christi) compared to a topical betamethasone ointment on the severity of clinical symptoms in patients with hand eczema: A randomized controlled clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250428065504N1

Enrollment

Registered

2025-07-11

Start date

2025-06-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hand eczema. Allergic contact dermatitis, unspecified cause

Interventions

Intervention 1: Intervention group: Herbal topical product (Myrtus communis L., Lawsonia inermis L., Ziziphus spina-christi) with a concentration of 1.5%, once a night at the site of eczema. Made by N

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-60 years Patients with hand eczema with mild involvement need treatment or moderate Patients with hand eczema who have not received any topical medication for 14 days prior to the study Patients who consent to participate in the study.

Exclusion criteria

Exclusion criteria: Having another skin disease Presence of end-stage underlying liver or kidney disease Pregnant and lactating mothers Use of systemic corticosteroids or immunosuppressants within the last 8 weeks Local infection at the site of eczema

Design outcomes

Primary

Measure	Time frame
Itching severity. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Visual Analog Scale.;Erythema. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Hand Eczema Severity Index(HECSI).;Irritation. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Visual Analog Scale(VAS).;Dryness, cracking, and peeling skin. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Hand Eczema Severity Index.;Papule. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Hand Eczema Severity Index.	—

Measure

Time frame

Itching severity. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Visual Analog Scale.;Erythema. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Hand Eczema Severity Index(HECSI).;Irritation. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Visual Analog Scale(VAS).;Dryness, cracking, and peeling skin. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Hand Eczema Severity Index.;Papule. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Hand Eczema Severity Index.

—

Secondary

Measure	Time frame
Quality of life. Timepoint: At the beginning of the study and one month after the start of treatment. Method of measurement: Dermatology Life Quality Index.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaegheh Hasanzadeh

Gorgan University of Medical Sciences

dr.hasanzadeh@goums.ac.ir+98 17 3255 6152

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026