traumatic brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: Administration of a single intramuscular dose of 300,000 IU vitamin D3 within 24 hours of admission, in addition to standard care for moderate to severe traumatic b
Sponsors
Bandare-abbas University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age between 18 to 70 GCS between 3 to 12 Patient with traumatic brain injury D3 Level less than 30 ng/ml
Exclusion criteria
Exclusion criteria: Age under 18 Age above 70 Death in first 72 hours Ca level more than 10.8 mg/dl Sufficient vitamin D level Usage of Corticosteroids in last 2 weeks Usage of Statins in last 2 weeks Pregnant and breastfeed women Usage of vitamin D supplements Patients with heart failure Patients with kidney failure Patients with liver failure Patients with autoimmune disease Patients with cancer Patients with epilepsy Patients with sepsis Patients with chronic use of Phenobarbital and other barbiturates Patients with chronic use of Rifampicin Patients with chronic use of Phenytoin Patients with chronic use of Carbamazepin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of Vitamin D Supplementation on Outcomes in Patients With Moderate to Severe Traumatic. Timepoint: 2025-2026. Method of measurement: Glasgow Coma Scale (GCS) score; Marshall score; Rotterdam score; Extended Glasgow Coma Scale (GCS-E) score; Acute Physiology and Chronic Health Evaluation II (APACHE II) score; Sequential Organ Failure Assessment (SOFA) score; length of ICU stay (days); total hospital length of stay (days); duration of mechanical ventilation (days); C-reactive protein (CRP) level; ferritin level; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; serum vitamin D level; interleukin-6 (IL-6) level. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSahra Afshin
Bandare-abbas University of Medical Sciences
Outcome results
None listed