Investigation of the Effect of Elaeagnus angustifolia Extract Gel Containing Nanohydroxyapatite Loaded with Crocin in the Treatment of Diabetic Ulcers

Comparing the effects of Elaeagnus angustifolia extract gel with crocin-loaded nanohydroxyapatite versus standard care on diabetic foot ulcer healing.

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250426065477N1

Enrollment

Registered

2025-05-14

Start date

2025-09-11

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabete. Diabetes mellitus due to underlying condition

Interventions

Intervention 1: Control group: This group includes patients with diabetic foot ulcers who are in stages 1 and 2 on the Wagner scale, and in addition to controlling blood sugar, their wounds are washed

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with diabetic foot ulcers who are in Wagner stage 1 or 2. have no clinical signs of infection. have controlled blood sugar and A1C levels. Willing to sign a consent form and agree to the study process, evaluation, and follow-up.

Exclusion criteria

Exclusion criteria: Patients who have recently received radiation or chemotherapy. Patients with suspected malignancy or other ulcer formation. Patients who are pregnant or breastfeeding. Patients with infected wounds.

Design outcomes

Primary

Measure	Time frame
Wound healing. Timepoint: Day Zero, Day 10, Day 20. Method of measurement: Square millimeter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsaneh Azaryan

Birjand University of Medical Sciences

ehsaneh.azaryan@gmail.com+98 56 3238 1235

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026