Effects of multicomponent training in multiple sclerosis patients

The effects of 12 weeks of multicomponent training and 8 weeks of follow-up on inflammatory and cardiometabolic markers, physical performance, and body composition in patients with multiple sclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250424065460N1

Enrollment

Registered

2025-06-23

Start date

2025-05-15

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple sclerosis. Multiple sclerosis

Interventions

Intervention 1: Intervention group: This group will participate in multi-component training with gradual increase in intensity for 12 weeks, three sessions per week, each session lasting 40 minutes. E

Eligibility

Sex/Gender

All

Age

25 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients can walk, sit, and stand up Extensive disability status scale (EDSS) in the low (between 2 and 3) to moderate (between 3 and 4) range Multiple sclerosis confirmed by a neurologist

Exclusion criteria

Exclusion criteria: Participating in any regular sports activity for 6 months prior to the present study Being pregnant for women Smoking

Design outcomes

Primary

Measure	Time frame
Tumor necrosis factor alpha (TNF-a). Timepoint: Pre-intervention (24 hours before the intervention) and post-intervention (24 hours after the final session of the 12-week training program). Method of measurement: Enzyme-linked immunosorbent assay (ELISA) of fasting blood samples.;Interleukin 6 (IL-6). Timepoint: Pre-intervention (24 hours before the intervention) and post-intervention (24 hours after the final session of the 12-week training program). Method of measurement: Enzyme-linked immunosorbent assay (ELISA) of fasting blood samples.;C-reactive protein (CRP). Timepoint: Pre-intervention (24 hours before the intervention) and post-intervention (24 hours after the final session of the 12-week training program). Method of measurement: Quantitative CRP diagnostic kit of fasting blood samples.;Leptin. Timepoint: Pre-intervention (24 hours before the intervention), post-intervention (24 hours after the final session of the 12-week training program), and post-follow-up (24 hours after the 8 weeks of follow-up). Method of measurement: Enzyme-linked immunosorbent assay (ELISA) of fasting blood samples.;Triglycerides (TG). Timepoint: Pre-intervention (24 hours before the intervention), post-intervention (24 hours after the final session of the 12-week training program), and post-follow-up (24 hours after 8 weeks of follow-up). Method of measurement: TG quantitative assay kit for fasting blood samples.;Low-density Lipoprotein Cholesterol (LDL-C). Timepoint: Pre-intervention (24 hours before the intervention), post-intervention (24 hours after the final session of the 12-week training program), and post-follow-up (24 hours after 8 weeks of follow-up). Method of measurement: LDL-C quantitative determination kit for fasting blood samples.;High-density Lipoprotein Cholesterol (HDL-C). Timepoint: Pre-intervention (24 hours before the intervention), post-intervention (24 hours after the final session of the 12-week training program), and post-follow-up (24 hours after 8 weeks	—

Measure

Time frame

Tumor necrosis factor alpha (TNF-a). Timepoint: Pre-intervention (24 hours before the intervention) and post-intervention (24 hours after the final session of the 12-week training program). Method of measurement: Enzyme-linked immunosorbent assay (ELISA) of fasting blood samples.;Interleukin 6 (IL-6). Timepoint: Pre-intervention (24 hours before the intervention) and post-intervention (24 hours after the final session of the 12-week training program). Method of measurement: Enzyme-linked immunosorbent assay (ELISA) of fasting blood samples.;C-reactive protein (CRP). Timepoint: Pre-intervention (24 hours before the intervention) and post-intervention (24 hours after the final session of the 12-week training program). Method of measurement: Quantitative CRP diagnostic kit of fasting blood samples.;Leptin. Timepoint: Pre-intervention (24 hours before the intervention), post-intervention (24 hours after the final session of the 12-week training program), and post-follow-up (24 hours after the 8 weeks of follow-up). Method of measurement: Enzyme-linked immunosorbent assay (ELISA) of fasting blood samples.;Triglycerides (TG). Timepoint: Pre-intervention (24 hours before the intervention), post-intervention (24 hours after the final session of the 12-week training program), and post-follow-up (24 hours after 8 weeks of follow-up). Method of measurement: TG quantitative assay kit for fasting blood samples.;Low-density Lipoprotein Cholesterol (LDL-C). Timepoint: Pre-intervention (24 hours before the intervention), post-intervention (24 hours after the final session of the 12-week training program), and post-follow-up (24 hours after 8 weeks of follow-up). Method of measurement: LDL-C quantitative determination kit for fasting blood samples.;High-density Lipoprotein Cholesterol (HDL-C). Timepoint: Pre-intervention (24 hours before the intervention), post-intervention (24 hours after the final session of the 12-week training program), and post-follow-up (24 hours after 8 weeks

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Kargarfard

University of Isfahan

M.Kargarfard@spr.ui.ac.ir+98 31 3793 2571

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026