knee osteoarteritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Autologous PRP will be prepared using a standardized two-step centrifugation protocol to ensure reproducibility and consistency. From each participant, 20 mL of peripheral venous blood
the remaining upper plasma will be discarded as platelet-poor plasma (PPP). Platelet and leukocyte counts will be measured from both baseline whole blood and final PRP samples using an automated hemat
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: mild to moderate knee osteoarthritis (stages of 2 and 3 based on Kellgren- Lawrence scale) Both sexes Aged = 45 years No severe swelling or inflammation of the knee joint or recent severe knee trauma within the past month. One or both knees affected, with injection will perform only for one eligible knee based on patient choice
Exclusion criteria
Exclusion criteria: no cooperation with researcher use of NSAID one week before or after injection or use of corticosteroid related drugs one month before and after injection technical problems which impair preparation of appropriate samples of PRP or PRF such as sample blood clotting before injection uncontrolled diabetes anemia ( hemoglobin less than 11 for females and less than 12 for males) thrombocytopenia ( less than 100000) malignancy skin infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain based on visual analog scale. Timepoint: 1,3, 6, and 12 months. Method of measurement: Visual analog scale questionnaire.;Loss of knee range of motion. Timepoint: 1,3, 6, and 12 months. Method of measurement: gunya.;Functional impairment. Timepoint: 1,3, 6, and 12 months. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index questionnaire.;Quality of life. Timepoint: 1,3, 6, and 12 months. Method of measurement: The 36-Item Short Form Survey (SF-36) questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee osteoarthritis grade. Timepoint: before intervention and one year after intervention. Method of measurement: The Kellgren and Lawrence grading system ( plain knee radiography). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahram Mohaghegh
Iran University of Medical Sciences
Outcome results
None listed