The comparative efficacy of bupivacaine 0.5% and combination of bupivacaine 0.5% and lidocaine 2% in infraclavicular block

The comparative efficacy of bupivacaine 0.5% and combination of bupivacaine 0.5% and lidocaine 2% in ultrasound guided infraclavicular block in patients with upper limb fractures: A randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250422065437N1

Enrollment

Registered

2025-09-16

Start date

2025-09-23

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Upper limb fractures. Fracture of upper limb, level unspecified

Interventions

Intervention 1: Control group: Ultrasonography probe wil be placed medial to coracoid and in a sagittal plane. After visualizing the medial, lateral and posterior cord around the axillary artery, a 18

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 18-65 Body mass index (BMI) ranging from 20 to 35 kg/m² Upper limb fracture

Exclusion criteria

Exclusion criteria: Requiring more than one fixation in the affected limb Allergy to opioids, acetaminophen, local anesthetics and nsaids Patients with chronic pain syndromes Patients abusing alcohol, opioids ant other anti legal drugs Renal dysfunction (edema, shortness of breath, malaise, hematuria, insomnia) Hepatic dysfunction (jaundice, ascitis, loss of consciousness, malaise, nausa, vomiting) Patients with neuromuscular disease Patients with psychological disease Loss of consciousness Pregnancy Infection at the site of procedure Patients with coagulation disease or taking anti-coagulant agents except Aspirin Reluctance to participation in this study

Design outcomes

Primary

Measure	Time frame
Onset of complete sensory block. Timepoint: Every 1 minute up to 10 minutes, every 2 minutes up to 10 minutes and then every 5 minutes up to 10 minutes or complete anethesia. Method of measurement: Hollman scale with pinprick test.;Onset of complete motor block. Timepoint: Every 5 minutes up to 30 minutes. Method of measurement: Physical examination of thumb abduction (radial nerve), third finger flexion (median nerve), fifth finger flexion (ulnar nerve) and elbow flexion (musculocutaneous).	—

Measure

Time frame

Onset of complete sensory block. Timepoint: Every 1 minute up to 10 minutes, every 2 minutes up to 10 minutes and then every 5 minutes up to 10 minutes or complete anethesia. Method of measurement: Hollman scale with pinprick test.;Onset of complete motor block. Timepoint: Every 5 minutes up to 30 minutes. Method of measurement: Physical examination of thumb abduction (radial nerve), third finger flexion (median nerve), fifth finger flexion (ulnar nerve) and elbow flexion (musculocutaneous).

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Secondary

Measure	Time frame
Duration of sensory block. Timepoint: Every 5 minutes after the onset of complete sensory block. Method of measurement: Time between the onset of complete sensory block to first sensation of pain or patient request for painkillers.;Duration of motor block. Timepoint: Every 5 minutes after the onset of complete motor block. Method of measurement: Time between the onset of complete motor block to return of finger functions (Grade 2 in Hollmen Scale).	—

Measure

Time frame

Duration of sensory block. Timepoint: Every 5 minutes after the onset of complete sensory block. Method of measurement: Time between the onset of complete sensory block to first sensation of pain or patient request for painkillers.;Duration of motor block. Timepoint: Every 5 minutes after the onset of complete motor block. Method of measurement: Time between the onset of complete motor block to return of finger functions (Grade 2 in Hollmen Scale).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPouya Sharifi

Tehran University of Medical Sciences

pouyasrf94@gmail.com+98 905 458 2517

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026