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The Effect of Xylapy cream 5% on Postoperative Sore Throat in Adults

Investigating the Effect of Xylapy cream 5% on Postoperative Sore Throat in Adults Following General Anesthesia with a Laryngeal Mask Airway: A Double-Blind Clinical Trial Study"

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250421065412N1
Enrollment
300
Registered
2025-05-29
Start date
2025-05-05
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia methods in surgeries.

Interventions

Intervention 1: Intervention group: In this group, Zylapril 5% cream (a topical anesthetic combining 2.5% lidocaine + 2.5% prilocaine, manufactured by Tehran Chemi Pharmaceutical Company) will be appl

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adult patients of both genders, aged 18 to 65 years, classified as ASA (American Society of Anesthesiologists) physical status I and II, who are candidates for surgery lasting 1 to 3 hours under general anesthesia with a laryngeal mask airway

Exclusion criteria

Exclusion criteria: Known hypersensitivity to local anesthetics More than two attempts required for Laryngeal Mask Airway insertion. Patients undergoing head and neck surgeries involving the airway. Airway injuries Preoperative pharyngeal pain Congenital oral anomalies. Loose or artificial dentures Anticipated difficult airway.

Design outcomes

Primary

MeasureTime frame
Postoperative sore throat rate. Timepoint: Patients will be assessed for the incidence and severity of postoperative sore throat at two times: once after surgery and during recovery, and a second time 3 hours after surgery. Method of measurement: Using a Likert scale that divides severity into category 1: mild; category 2: moderate; category 3: severe.;Coughing after surgery. Timepoint: After surgery in recovery and 3 hours after surgery,. Method of measurement: Questioning the patient.;Voice change after surgery. Timepoint: After surgery in recovery and 3 hours after surgery,. Method of measurement: Questioning the patient.;Hypoxia. Timepoint: After surgery in recovery and 3 hours after surgery. Method of measurement: Pulse Oximeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSina forghani

Iran University of Medical Sciences

drsinaforghani@gmail.com+98 21 86721

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026