The effect of MIND Diet compared with multivitamin-mineral supplementation and weight loss diet on premenstrual syndrome

Investigating the effect of MIND Diet compared to multivitamin mineral supplement and weight loss diet on physical, mental and behavioral symptoms of premenstrual syndrome, some biochemical parameters and serum orexin level in overweight or obese women with premenstrual syndrome

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250420065397N1

Enrollment

Registered

2025-08-07

Start date

2025-08-15

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premenstrual Syndrome. Premenstrual tension syndrome

Interventions

Intervention 1: Intervention group 1: Receiving MIND diet for 4 menstrual cycles. In this group, it is recommended to consume green leafy vegetables (6 or more servings per week), other vegetables (1

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women with moderate to severe premenstrual syndrome Regular menstrual cycle Age range 18-40 years Overweight or obese (body mass index 25-34.9 kg/m2)

Exclusion criteria

Exclusion criteria: pregnancy breastfeeding Taking sedatives and psychotropic drugs Taking vitamin supplements Following any special diet

Design outcomes

Primary

Measure	Time frame
Premenstrual syndrome physical symptom score. Timepoint: before and after intervention. Method of measurement: Rossignol and Bonlander Questionnaire.;Estrogen. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;Progesterone. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;Prolactin. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;TNF-a. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;HsCRP. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;Total antioxidant capacity. Timepoint: before and after intervention. Method of measurement: Calorimetry.;Orexin. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;Premenstrual syndrome mental symptom score. Timepoint: before and after intervention. Method of measurement: Rossignol and Bonlander Questionnaire.;Premenstrual syndrome behavioral symptom score. Timepoint: before and after intervention. Method of measurement: Rossignol and Bonlander Questionnaire.	—

Measure

Time frame

Premenstrual syndrome physical symptom score. Timepoint: before and after intervention. Method of measurement: Rossignol and Bonlander Questionnaire.;Estrogen. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;Progesterone. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;Prolactin. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;TNF-a. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;HsCRP. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;Total antioxidant capacity. Timepoint: before and after intervention. Method of measurement: Calorimetry.;Orexin. Timepoint: before and after intervention. Method of measurement: Enzyme Linked Immuno sorbent Assay.;Premenstrual syndrome mental symptom score. Timepoint: before and after intervention. Method of measurement: Rossignol and Bonlander Questionnaire.;Premenstrual syndrome behavioral symptom score. Timepoint: before and after intervention. Method of measurement: Rossignol and Bonlander Questionnaire.

—

Secondary

Measure	Time frame
Weight. Timepoint: before and after intervention. Method of measurement: Digital scale.;Body mass index. Timepoint: before and after intervention. Method of measurement: Dividing weight (in kilograms) by the square of height (in meters).;Waist circumference. Timepoint: before and after intervention. Method of measurement: Tape measure.;Hip circumference. Timepoint: before and after intervention. Method of measurement: Tape measure.;Waist to hip ratio. Timepoint: before and after intervention. Method of measurement: Dividing waist circumference (in centimeters) by the hip circumference (in centimeters).	—

Measure

Time frame

Weight. Timepoint: before and after intervention. Method of measurement: Digital scale.;Body mass index. Timepoint: before and after intervention. Method of measurement: Dividing weight (in kilograms) by the square of height (in meters).;Waist circumference. Timepoint: before and after intervention. Method of measurement: Tape measure.;Hip circumference. Timepoint: before and after intervention. Method of measurement: Tape measure.;Waist to hip ratio. Timepoint: before and after intervention. Method of measurement: Dividing waist circumference (in centimeters) by the hip circumference (in centimeters).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mostafa Nachvak

Kermanshah University of Medical Sciences

smnachvak@hotmail.com+98 83 3710 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026